Here we can find the coefficient of x53 in the given expression We know that Binomial theorem for positive integral index If a , b are any two real numbers and n any natural number then (a+b)n = (0n)anb0 + (1n)an−1b + (2n)an−2b2 + ... + (rn)an−rbr + ... + (nn)x0bn , where (rn) = (n−r)!r!n! Here (0n),(1n),(2n) ... (nn) are called binomial coefficients i.e., (a+b)n = r=0∑n(rn)an−rbr Given m=0∑100100Cm(x−3)100−m⋅2m On expanding the summation , we have , = 100C0(x−3)100+100C1(x−3)99⋅2 + 100C2(x−3)98⋅22 + ... + 100C100⋅2100 = [(x−3)+2]100 = (x−1)100 = (1−x)100 (Since, the power is even, by binomial expansion) Therefore, coefficient of x53 = (−1)53⋅(53100) = −(53100) Hence, The coefficient of x53 in the expression of m=0∑100100Cm(x−3)100−m⋅2m = −(53100) another method : we have m=0∑100100Cm(x−3)100−m⋅2m = [(x−3)+2]100 = (1−x)100 Therefore, coefficient of x53 = (53100)(−1)53 = −(53100)m=0∑100100Cm(x−3)100−m⋅2m = −(53100)