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KVPY SX SB Exam 2015 Question Paper
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© examsnet.com
Question : 120
Total: 120
Enzyme X catalyzes hydrolysis of GTP into GDP. The GTP-bound form of X transmits a signal that leads to cell proliferation. The GDP – bound form does not transmit any such signal. Mutations in X are found in many cancers. Which of the following alterations of X are most likely to contribute to cancer?
Mutations that increase the affinity of X for GDP
Mutations that decrease the affinity of X for GTP
Mutations that decrease the rate of GTP hydrolysis
Mutations that prevent expression of enzyme X.
Validate
Solution:
GTP –X Complex
–
–
–
–
–
–
▸
Active cell division
GDP –X Complex
–
–
–
–
–
–
▸
No cell division
and
GTP
Hydrolysis
–
–
–
–
–
–
–
–
–
▸
X
enzyme
GDP
Mutation cause the decrease of rate of hydrolysis of GTP. Thus GTP –X complex remain present for long time and cell division become uncontrolled
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