Concept:Differentiate the inverse sine function using the chain rule and then evaluate at the given point.Explanation:Let u=1+x22x. Then f(x)=sin−1u.Using the chain rule, f′(x)=1−u2u′.First, differentiate u with respect to x:u′=(1+x2)2(1+x2)(2)−2x(2x)u′=(1+x2)22+2x2−4x2=(1+x2)22(1−x2).Now compute 1−u2:1−u2=1−(1+x22x)21−u2=(1+x2)2(1+x2)2−4x2=(1+x2)2(1−x2)2.Thus, 1−u2=1+x2∣1−x2∣.At x=21, we have 1−x2>0, so 1−u2=1+x21−x2.Substitute into the derivative formula:f′(x)=1+x21−x2(1+x2)22(1−x2)=1+x22.Evaluate at x=21:f′(21)=1+(21)22=1+412=452=58.Answer:58, which is option A.