All enzymes that utilize ATP in phosphate transfer require Mg as the co-factor. Bone in human body is not an inert and unchanging substance but is continuously being solubilised and redeposited. Ca plays important role in neuromuscular function, interneuronal transmission, cell membrane integrity and blood coagulation. The daily requirement of Mg and Ca in the human body is estimated to be 200−300mg(0.2−0.3g)